بیماران مبتلا به اختلال ملال پیش از قاعدگی مدولاسیون وحشت زدگی را در طول پیش بینی در دوره اواخر فاز لوتئال در مقایسه با کنترل افراد افزایش داده است

Compared with control subjects, PMDD patients displayed an enhanced startle modulation by positive and negative anticipation stimuli in the luteal phase of the menstrual cycle. This finding was mainly driven by increased modulation in the luteal phase in comparison to the follicular phase among PMDD patients but also by an increased modulation in patients compared to controls during luteal phase. This suggests that the neural circuits underlying response to emotional anticipation are more sensitive during this period and emphasize the need of examining the neural correlates of anticipatory processes in women with PMDD.