اثرات هورمون جنسی متقابل بر فعال سازی مغزی در طول زبان و چرخش ذهنی: مطالعه fMRI در تراجنسی

fMRI scans were obtained from 6 female-to-male and 8 male-to-female transsexuals at baseline and after cross-sex steroid treatment. Activation was measured during language and mental rotation tasks. Language activation increased after sex steroid treatment in both groups (F(1,12) = 3.7, p = 0.08), and total language activity was correlated to post-treatment estradiol levels (rho = 0.54, p = 0.05). Lateralization was not affected by the reversal of sex steroid milieus (F(1,12) = 1.47, p = 0.25). Activation during mental rotation did not increase during treatment (F(1,12) = 0.54, p = 0.34), but post-treatment testosterone levels correlated to total activation during mental rotation (rho = 0.64, p = 0.01). Findings suggest that sex steroids may influence cerebral activation, but lateralization remains stable.