دانلود مقاله ISI انگلیسی شماره 128730
ترجمه فارسی عنوان مقاله

راه های عصبی مختلف برای فراخوانی حافظه ی خودکار در افراد سالم و افراد مبتلا به صرع لوب مدفوع چپ

عنوان انگلیسی
Different neural routes to autobiographical memory recall in healthy people and individuals with left medial temporal lobe epilepsy
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
128730 2018 40 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 110, February 2018, Pages 26-36

ترجمه کلمات کلیدی
ساخت و ساز، پیچیدگی، هیپوکامپ، قشر پیشروی مغز ونتومدیال، اتصال به عملکرد انعطاف پذیری،
کلمات کلیدی انگلیسی
Construction; Elaboration; Hippocampus; Ventromedial prefrontal cortex; Functional connectivity; Flexibility;
پیش نمایش مقاله
پیش نمایش مقاله  راه های عصبی مختلف برای فراخوانی حافظه ی خودکار در افراد سالم و افراد مبتلا به صرع لوب مدفوع چپ

Individuals with medial temporal lobe epilepsy (mTLE) are poor at recalling vivid details from autobiographical memories (AM), instead retrieving gist-like schematic memories. Recent research has suggested that this impoverished recall in comparison to controls may reflect (1) differential engagement of anterior vs posterior regions of the hippocampus (HC) and/or (2) differences between the engagement of the HC vs the ventromedial prefrontal cortex (vmPFC). Here we examined these hypotheses by comparing connectivity amongst hippocampal regions and between vmPFC and other brain regions during construction (retrieval of a particular event) vs elaboration (retrieval of perceptual detail) phases of AM recall in 12 individuals with left mTLE and 12 matched controls. Whereas functional connectivity amongst hippocampal regions changed from AM construction to elaboration in controls, the pattern of intra-hippocampal connectivity was unvarying in patients. Furthermore, patterns of connectivity from the vmPFC differed between phases in distinct ways in the two groups of participants. In patients, vmPFC activation was correlated with other prefrontal and lateral temporal cortices during construction and with visual-perceptual cortices during elaboration. While controls did not show a difference in whole-brain connectivity, they did uniquely show a dynamic shift from vmPFC connectivity to anterior HC during construction and to posterior HC during elaboration. Together, these findings suggest that impoverished AM recall in mTLE is a consequence of reduced activation and flexibility of bilateral hippocampal networks and greater reliance on neocortical contributions to memory retrieval.