مبانی عصبی رمزگذاری و یادآوری بینابینی در افراد سالم و افسرده

In non-depressed subjects, simply recalling a stimulus associated with a previous interoceptive challenge activated a key region in the brain’s interoceptive network. Although previous research has linked MDD with aberrant processing of interoceptive stimuli, the current study is the first to demonstrate that individuals with MDD exhibit decreased insula activity while recalling interoceptive memories. It is possible that insula hypo-activation during interoceptive recall may affect the representation of prior interoceptive experiences in ways that contribute to depressive symptomology and the relationship between depression and systemic health.