دانلود مقاله ISI انگلیسی شماره 158400
ترجمه فارسی عنوان مقاله

آنتاگونیز کردن مراحل مختلف فعال شدن گیرنده های اپوئیدی کاپا به طور انتخابی و مستقل، جذب و تثبیت خاطرات انجمنی را کاهش می دهد

عنوان انگلیسی
Antagonizing the different stages of kappa opioid receptor activation selectively and independently attenuates acquisition and consolidation of associative memories
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
158400 2017 41 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Behavioural Brain Research, Volume 323, 14 April 2017, Pages 1-10

پیش نمایش مقاله
پیش نمایش مقاله  آنتاگونیز کردن مراحل مختلف فعال شدن گیرنده های اپوئیدی کاپا به طور انتخابی و مستقل، جذب و تثبیت خاطرات انجمنی را کاهش می دهد

چکیده انگلیسی

Previous work from our laboratory has shown that nonspecific kappa opioid receptor (KOR) antagonism in primary somatosensory cortex (S1) can inhibit acquisition for the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB). Although studies have demonstrated that KOR activation can alter stimuli salience, our studies controlled for these factors, demonstrating that KOR also plays a role in facilitating learning. KOR has two distinct phases of activation followed by internalization/downregulation, that each independently activate kinases and transcription factors known to mediate task acquisition and memory consolidation respectively. The current study demonstrated that antagonism of the initial phase of KOR activation in S1 via local injections of the g-protein inhibitor, pertussis toxin (PTX), blocked initial WTEB acquisition without affecting retention of the association. In contrast, KOR late phase antagonism in S1 via local injections of the GRK3-specific antagonist, guanidinonaltrindole (GNTI), blocked retention of the WTEB association without affecting task acquisition. Consistent with the known mechanism for KOR activation, KOR protein expression in S1 was found to be decreased following WTEB training, further supporting the involvement of neocortical KOR activation with learning. Prior studies have shown that task acquisition and memory consolidation are mediated by distinct molecular processes; however, little is known regarding a potential mechanism driving these processes. The current study suggests that neocortical KOR activation mediates activation of these processes with learning. This study provides the first evidence for a time- and learning-dependent property of neocortical KOR in facilitating acquisition and consolidation of associative memories, while elucidating an unexplored neocortical learning mechanism.