دانلود مقاله ISI انگلیسی شماره 60789
ترجمه فارسی عنوان مقاله

سنتز ماکرومولکولی، توزیع شکل پذیری سیناپسی و شرطی سازی ترس

عنوان انگلیسی
Macromolecular synthesis, distributed synaptic plasticity, and fear conditioning
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
60789 2008 14 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 89, Issue 3, March 2008, Pages 324–337

ترجمه کلمات کلیدی
شرطی سازی ترس؛ یادگیری؛ حافظه؛ سنتز پروتئین؛ رونویسی؛ ترجمه؛ پاولووسکی؛ بروز ژن
کلمات کلیدی انگلیسی
Fear conditioning; Learning; Memory; Protein synthesis; Transcription; Translation; Pavlovian; Gene expression
پیش نمایش مقاله
پیش نمایش مقاله  سنتز ماکرومولکولی، توزیع شکل پذیری سیناپسی و شرطی سازی ترس

چکیده انگلیسی

Recent work from a number of laboratories has provided new and important insights about how gene expression is altered by experience and how these molecular changes may provide a substrate for the long-term storage of new memories. Here, we review a series of recent studies using aversive Pavlovian conditioning in rats as a well characterized model system in which experience-dependent alterations in gene expression can be manipulated and quantified within a specific neural circuit. We highlight some of the issues involved in using broad-spectrum inhibitors of mRNA and protein synthesis to study cellular changes underlying the formation and long-term stability of memory and discuss the idea that these changes occur over widespread, behaviorally-defined, networks of cells. We also discuss the idea that the maintenance of memory and its susceptibly to disruption after retrieval may relate to local protein synthesis in dendrites. Finally, a series of recent experiments from our laboratory studying the role of a specific signaling pathway (mTOR) which regulates translational processes and memory formation in the amygdala and hippocampus during fear conditioning are reviewed.