دانلود مقاله ISI انگلیسی شماره 71525
ترجمه فارسی عنوان مقاله

گلوکوکورتیکوئیدها با سیستم تحریک کردن نورآدرنرژیک در پوسته هسته اکومبنس ارتباط برقرار می کنند تا تقویت کننده حافظه از طعم و مزه اشتها و طعم دهنده

عنوان انگلیسی
Glucocorticoids interact with the noradrenergic arousal system in the nucleus accumbens shell to enhance memory consolidation of both appetitive and aversive taste learning
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
71525 2012 9 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 98, Issue 2, September 2012, Pages 197–205

ترجمه کلمات کلیدی
کورتیکواسترون، نوراپی نفرین، تضعیف نئوفوبیا، بی حوصلگی طعمدار ارزشیابی
کلمات کلیدی انگلیسی
Corticosterone; Norepinephrine; Attenuation of neophobia; Conditioned taste aversion; Valence

چکیده انگلیسی

It is well established that glucocorticoid hormones strengthen the consolidation of long-term memory of emotionally arousing experiences but have little effect on memory of low-arousing experiences. Although both positive and negative emotionally arousing events tend to be well remembered, studies investigating the neural mechanism underlying glucocorticoid-induced memory enhancement focused primarily on negatively motivated training experiences. In the present study we show an involvement of glucocorticoids within the nucleus accumbens (NAc) in enhancing memory consolidation of both an appetitive and aversive form of taste learning. The specific glucocorticoid receptor (GR) agonist RU 28362 (1 or 3 ng) administered bilaterally into the NAc shell, but not core, of male Sprague–Dawley rats immediately after an appetitive saccharin drinking experience dose-dependently enhanced 24-h retention of the safe taste, resulting in a facilitated attenuation of neophobia. Similarly, GR agonist infusions given into the NAc shell immediately after pairing of the saccharin taste with a malaise-inducing agent enhanced memory of this negative experience, resulting in an intensified conditioned aversion. Importantly, a suppression of noradrenergic activity within the NAc shell with the β-adrenoceptor antagonist propranolol blocked the facilitating effect of a concurrently administered GR agonist on memory consolidation in both the appetitive and aversive learning task. Thus, these findings indicate that GR activation interacts with the noradrenergic arousal system within the NAc to enhance memory consolidation of emotionally arousing training experiences regardless of valence.