دانلود مقاله ISI انگلیسی شماره 71556
ترجمه فارسی عنوان مقاله

تثبیت حافظه آفلاین دچار اختلال شده در افسردگی

عنوان انگلیسی
Impaired off-line memory consolidation in depression
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
71556 2010 9 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 20, Issue 8, August 2010, Pages 553–561

ترجمه کلمات کلیدی
افسردگی؛ خواب؛ حافظه
کلمات کلیدی انگلیسی
Depression; Sleep; Memory
پیش نمایش مقاله
پیش نمایش مقاله  تثبیت حافظه آفلاین دچار اختلال شده در افسردگی

چکیده انگلیسی

50 medicated patients with an acute episode of MD, 50 normal controls and 12 patients with a remitted episode of MD were assessed using a sequential finger tapping task before and after a night of sleep. Although depressed patients and control subjects did not differ in practice-dependent learning, healthy subjects showed markedly overnight improvements in tapping performance of 18% while patients failed to show any improvement. This pattern became even more striking when the subjects were divided by an age threshold of 30 years: In the 30+ yrs group the healthy subjects showed 16% overnight increase in motor performance, whereas the patients showed − 10% overnight decrease. In contrast, patients and controls in the ≤ 30 yrs group showed virtually the same motor performance, as well as remitted patients and controls in the 30+ yrs group. In addition, the younger controls showed stronger overnight improvements than the older controls. This pattern might be interpreted as a synergistic interaction between age and depression: Off-line motor memory consolidation is not affected in young patients, but severely impaired in older patients with an acute episode of MD. This impairment seems to recover after remission from depression.