دانلود مقاله ISI انگلیسی شماره 71933
ترجمه فارسی عنوان مقاله

کاهش حجم هیپوکامپ و نقص حافظه شرح حال در اسکیزوفرنی مزمن

عنوان انگلیسی
Hippocampal volume reduction and autobiographical memory deficits in chronic schizophrenia
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
71933 2013 6 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 211, Issue 3, 30 March 2013, Pages 189–194

ترجمه کلمات کلیدی
تصویربرداری رزونانس مغناطیسی (MRI)؛ هیپوکامپ؛ FSL؛ نوروسایکولوژی؛ سازه های تحت قشری؛ لوب تمپورال داخلی (MTL)
کلمات کلیدی انگلیسی
Magnetic resonance imaging (MRI); Hippocampus; FSL; Neuropsychology; Subcortical structures; Medial temporal lobe (MTL)
پیش نمایش مقاله
پیش نمایش مقاله  کاهش حجم هیپوکامپ و نقص حافظه شرح حال در اسکیزوفرنی مزمن

چکیده انگلیسی

Although autobiographical memory (AM) deficits and hippocampal changes are frequently found in schizophrenia, their actual association remained yet to be established. AM performance and hippocampal volume were examined in 33 older, chronic schizophrenic patients and 21 healthy volunteers matched for age, gender and education. Psychopathological symptoms and additional neuropsychological parameters were assessed by using appropriate rating scales; magnetic resonance imaging (MRI) 3-T data were analyzed via an automated region-of-interest procedure. When compared with the control subjects, patients showed significantly decreased left anterior and posterior hippocampal volumes. Episodic but not semantic AM performance was significantly lower in the patients than in the healthy controls. Both episodic and semantic AM deficits were significantly correlated with volume of the left hippocampus in the patient group. In contrast, deficits in verbal memory, working memory and remote semantic memory observed in the patients did not relate to hippocampal volume. Our findings indicate that AM deficits in chronic schizophrenia are associated with hippocampal volume reductions and underline the importance of this pathology in schizophrenia.