دانلود مقاله ISI انگلیسی شماره 119368
ترجمه فارسی عنوان مقاله

اثرات تعاملی تستوسترون و کورتیزول در حجم هیپوکامپ و حافظه اپیزودیک در مردان میانسال

عنوان انگلیسی
Interactive effects of testosterone and cortisol on hippocampal volume and episodic memory in middle-aged men
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
119368 2018 8 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 91, May 2018, Pages 115-122

ترجمه کلمات کلیدی
تستوسترون، کورتیزول، هیپوکامپ، حافظه اپیزودیک،
کلمات کلیدی انگلیسی
Testosterone; Cortisol; Hippocampus; Episodic memory;
پیش نمایش مقاله
پیش نمایش مقاله  اثرات تعاملی تستوسترون و کورتیزول در حجم هیپوکامپ و حافظه اپیزودیک در مردان میانسال

چکیده انگلیسی

Animal and human research suggests that testosterone is associated with hippocampal structure and function. Studies examining the association between testosterone and either hippocampal structure or hippocampal-mediated cognitive processes have overwhelmingly focused on the effects of testosterone alone, without considering the interaction of other neuroendocrine factors. The aim of the present study was to examine the interactive effects of testosterone and cortisol in relation to hippocampal volume and episodic memory in a sample of late-middle aged men from the Vietnam Era Twin Study of Aging. The average age of participants was 56.3 years (range 51–60). Salivary hormone samples were collected at multiple time-points on two non-consecutive at-home days, and an in-lab assessment. Area under the curve with respect to ground measures for cortisol and testosterone were utilized. Significant testosterone-by-cortisol interactions were observed for hippocampal volume, and episodic memory. When cortisol levels were elevated (1 SD above the mean), testosterone levels were positively associated with hippocampal volume and memory performance. However, when cortisol levels were low (1 SD below the mean), testosterone levels were inversely related to hippocampal volume and memory performance. These findings suggest that in context of high cortisol levels, testosterone may be neuroprotective. In contrast, low testosterone may also be neuroprotective in the context of low cortisol levels. To our knowledge this is the first demonstration of such an interaction in a structural brain measure and an associated cognitive ability. These results argue in favor of broadening neuroendocrine research to consider the simultaneous and interactive effects of multiple hormones on brain structure and function.