دانلود مقاله ISI انگلیسی شماره 119377
ترجمه فارسی عنوان مقاله

ارتباط طولی بین آتروفی هیپوکامپ و کاهش حافظه اپیزودیک-حافظه

عنوان انگلیسی
Longitudinal association between hippocampus atrophy and episodic-memory decline
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
119377 2017 40 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 51, March 2017, Pages 167-176

ترجمه کلمات کلیدی
سالخورده، کاهش شناختی، حافظه اپیزودیک، هیپوکامپ، تغییرات طولی سقوط غیر قابل انکار،
کلمات کلیدی انگلیسی
Aging; Cognitive decline; Episodic memory; Hippocampus; Longitudinal changes; Nonignorable attrition;
پیش نمایش مقاله
پیش نمایش مقاله  ارتباط طولی بین آتروفی هیپوکامپ و کاهش حافظه اپیزودیک-حافظه

چکیده انگلیسی

There is marked variability in both onset and rate of episodic-memory decline in aging. Structural magnetic resonance imaging studies have revealed that the extent of age-related brain changes varies markedly across individuals. Past studies of whether regional atrophy accounts for episodic-memory decline in aging have yielded inconclusive findings. Here we related 15-year changes in episodic memory to 4-year changes in cortical and subcortical gray matter volume and in white-matter connectivity and lesions. In addition, changes in word fluency, fluid IQ (Block Design), and processing speed were estimated and related to structural brain changes. Significant negative change over time was observed for all cognitive and brain measures. A robust brain-cognition change-change association was observed for episodic-memory decline and atrophy in the hippocampus. This association was significant for older (65–80 years) but not middle-aged (55–60 years) participants and not sensitive to the assumption of ignorable attrition. Thus, these longitudinal findings highlight medial-temporal lobe system integrity as particularly crucial for maintaining episodic-memory functioning in older age.