دانلود مقاله ISI انگلیسی شماره 119382
ترجمه فارسی عنوان مقاله

مصرف داروی آنتی کولینرژیک با کاهش حافظه اپیزودیک در افراد مسن سالم بدون زوال عقل همراه است

عنوان انگلیسی
Anticholinergic drug use is associated with episodic memory decline in older adults without dementia
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
119382 2017 24 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 55, July 2017, Pages 27-32

ترجمه کلمات کلیدی
داروهای آنتی کولینرژیک، شناخت، حافظه اپیزودیک، سالخورده، تفاوت بین فردی،
کلمات کلیدی انگلیسی
Anticholinergic drugs; Cognition; Episodic memory; Aging; Inter-individual differences;
پیش نمایش مقاله
پیش نمایش مقاله  مصرف داروی آنتی کولینرژیک با کاهش حافظه اپیزودیک در افراد مسن سالم بدون زوال عقل همراه است

چکیده انگلیسی

Anticholinergic drug use is common in older adults and has been related to increased dementia risk. This suggests that users of these drugs may experience accelerated cognitive decline. So far, however, longitudinal data on this topic are absent and the available evidence is inconclusive with respect to effects on specific cognitive domains due to suboptimal control of confounding variables. We investigated whether anticholinergic medication use is associated with cognitive decline over 6 years in a population-based study of older adults (aged 60–90; n = 1473) without dementia. We found that users (n = 29) declined more on episodic memory over 6 years compared to nonusers (n = 1418). These results were independent of age, sex, education, overall drug intake, physical activity, depression, cardiovascular risk burden, and cardiovascular disease. By contrast, anticholinergic drug use was unrelated to performance in processing speed, semantic memory, short-term memory, verbal fluency, and global cognition (the Mini-Mental-State Examination). Our results suggest that effects of anticholinergics may be particularly detrimental to episodic memory in older adults, which supports the assertion that the cholinergic system plays an important role in episodic memory formation.