دانلود مقاله ISI انگلیسی شماره 119424
ترجمه فارسی عنوان مقاله

اختلال عملکرد جدایی الگوی فضایی در صرع لوب فکری با کمبود حافظه فضایی و کاهش حجم هیپوکامپ همراه است

عنوان انگلیسی
Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
119424 2018 28 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 111, March 2018, Pages 209-215

ترجمه کلمات کلیدی
حافظه اپیزودیک، اختلال هیپوکامپ، لوب قدامی مدفوع، کاهش حافظه پیشرونده، حافظه فضایی،
کلمات کلیدی انگلیسی
Episodic memory; Hippocampal dysfunction; Medial temporal lobe; Progressive memory decline; Spatial memory;
پیش نمایش مقاله
پیش نمایش مقاله  اختلال عملکرد جدایی الگوی فضایی در صرع لوب فکری با کمبود حافظه فضایی و کاهش حجم هیپوکامپ همراه است

چکیده انگلیسی

Individuals with chronic temporal lobe epilepsy (TLE) experience episodic memory deficits that may be progressive in nature. These memory decrements have been shown to increase with the extent of hippocampal damage, a hallmark feature of TLE. Pattern separation, a neural computational mechanism thought to play a role in episodic memory formation, has been shown to be negatively affected by aging and in individuals with known hippocampal dysfunction. Despite the link between poor pattern separation performance and episodic memory deficits, behavioral pattern separation has not been examined in patients with TLE. We examined pattern separation performance in a group of 22 patients with medically-refractory TLE and 20 healthy adults, using a task hypothesized to measure spatial pattern separation with graded levels of spatial interference. We found that individuals with TLE showed less efficient spatial pattern separation performance relative to healthy adults. Poorer spatial pattern separation performance in TLE was associated with poorer visuospatial memory, but only under high interference conditions. In addition, left hippocampal atrophy was associated with poor performance in the high interference condition in TLE. These data suggest that episodic memory impairments in patients with chronic, refractory TLE may be partially due to less efficient pattern separation, which likely reflects their underlying hippocampal dysfunction.