دانلود مقاله ISI انگلیسی شماره 119432
ترجمه فارسی عنوان مقاله

چاقی و مقاومت به انسولین با کاهش فعالیت در مغز مرتبط است

عنوان انگلیسی
Obesity and insulin resistance are associated with reduced activity in core memory regions of the brain
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
119432 2017 43 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 96, February 2017, Pages 137-149

پیش نمایش مقاله
پیش نمایش مقاله  چاقی و مقاومت به انسولین با کاهش فعالیت در مغز مرتبط است

چکیده انگلیسی

Increasing research in animals and humans suggests that obesity may be associated with learning and memory deficits, and in particular with reductions in episodic memory. Rodent models have implicated the hippocampus in obesity-related memory impairments, but the neural mechanisms underlying episodic memory deficits in obese humans remain undetermined. In the present study, lean and obese human participants were scanned using fMRI while completing a What-Where-When episodic memory test (the “Treasure-Hunt Task”) that assessed the ability to remember integrated item, spatial, and temporal details of previously encoded complex events. In lean participants, the Treasure-Hunt task elicited significant activity in regions of the brain known to be important for recollecting episodic memories, such as the hippocampus, angular gyrus, and dorsolateral prefrontal cortex. Both obesity and insulin resistance were associated with significantly reduced functional activity throughout the core recollection network. These findings indicate that obesity is associated with reduced functional activity in core brain areas supporting episodic memory and that insulin resistance may be a key player in this association.