بسیاری از کارآزمایی های بالینی تصادفی ممکن است توجیه نگردند: تجزیه و تحلیل مقطعی از اخلاق و علم آزمایشات بالینی تصادفی

The majority of RCTs (56%) did not meet the three scientific criteria described previously and therefore may be scientifically and therefore ethically unjustified. We recommend that “equipoise,” “clinical equipoise,” and “lack of consensus” be abandoned as scientific criteria for RCTs and be replaced by an expectation that RCTs have a clearly stated, meaningful hypothesis around which uncertainty has been established through a systematic review of the literature.