بیماران مبتلا به اختلال افسردگی عمده نشانگر کاهش میزان پاداش در استریاتوم هستند

Patients with MDD exhibit reduced ability to modulate neural response when adjusting for variable amount of reward. This result suggests that reward size coding in the striatum may represent a neural correlate of motivational anhedonia in MDD patients.