دانلود مقاله ISI انگلیسی شماره 41233
ترجمه فارسی عنوان مقاله

قرار گرفتن در معرض پیری بلوط به هورمون های بیضه، پاسخ به محیط های جدید و رفتار اجتماعی در موش های صحرایی نر را سازماندهی می کند

عنوان انگلیسی
Peri-pubertal exposure to testicular hormones organizes response to novel environments and social behaviour in adult male rats
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی ترجمه فارسی
41233 2015 7 صفحه PDF سفارش دهید
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منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 73, July 2015, Pages 135–141

ترجمه کلمات کلیدی
بلوغ، تستوسترون، تفاوت های جنسی، اکتشاف، رفتار جنسی، اختگی
کلمات کلیدی انگلیسی
Adolescence; Testosterone; Sex differences; Exploration; Sexual behaviour; Castration

چکیده انگلیسی

Previous research has shown that exposure to testicular hormones during the peri-pubertal period of life has long-term, organizational effects on adult sexual behaviour and underlying neural mechanisms in laboratory rodents. However, the organizational effects of peri-pubertal testicular hormones on other aspects of behaviour and brain function are less well understood. Here, we investigated the effects of manipulating peri-pubertal testicular hormone exposure on later behavioural responses to novel environments and on hormone receptors in various brain regions that are involved in response to novelty. Male rodents generally spend less time in the exposed areas of novel environments than females, and this sex difference emerges during the peri-pubertal period. Male Lister-hooded rats (Rattus norvegicus) were castrated either before puberty or after puberty, then tested in three novel environments (elevated plus-maze, light–dark box, open field) and in an object/social novelty task in adulthood. Androgen receptor (AR), oestrogen receptor (ER1) and corticotropin-releasing factor receptor (CRF-R2) mRNA expression were quantified in the hypothalamus, hippocampus and medial amygdala. The results showed that pre-pubertally castrated males spent more time in the exposed areas of the elevated-plus maze and light–dark box than post-pubertally castrated males, and also confirmed that peri-pubertal hormone exposure influences later response to an opposite-sex conspecific. Hormone receptor gene expression levels did not differ between pre-pubertally and post-pubertally castrated males in any of the brain regions examined. This study therefore demonstrates that testicular hormone exposure during the peri-pubertal period masculinizes later response to novel environments, although the neural mechanisms remain to be fully elucidated.

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