دانلود مقاله ISI انگلیسی شماره 128236
ترجمه فارسی عنوان مقاله

تعاملات بین استرادیول و هالوپریدول در یادگیری بی قراری و معکوس در موشهای صحرایی ماده حساسیت آمفتامین

عنوان انگلیسی
Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
128236 2017 8 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 89, March 2017, Pages 113-120

ترجمه کلمات کلیدی
استروژن، ضد روانپزشکی، تنظیم حرکت، جنون جوانی،
کلمات کلیدی انگلیسی
Estrogens; Antipsychotic; Set-shifting; Schizophrenia;
پیش نمایش مقاله
پیش نمایش مقاله  تعاملات بین استرادیول و هالوپریدول در یادگیری بی قراری و معکوس در موشهای صحرایی ماده حساسیت آمفتامین

چکیده انگلیسی

There are sex differences associated with schizophrenia, as women exhibit later onset of the disorder, less severe symptomatology, and better response to antipsychotic medications. Estrogens are thought to play a role in these sex differences; estrogens facilitate the effects of antipsychotic medications to reduce the positive symptoms of schizophrenia, but it remains unclear whether estrogens protect against the cognitive symptoms of this disorder. Amphetamine sensitization is used to model some symptoms of schizophrenia in rats, including cognitive deficits like excessive perseveration and slower reversal learning. In this experiment female rats were administered a sensitizing regimen of amphetamine to mimic these cognitive symptoms. They were ovariectomized and administered either low or high estradiol replacement as well as chronic administration of the antipsychotic haloperidol, and were assessed in tests of perseveration and reversal learning. Results of these experiments demonstrated that, in amphetamine-sensitized rats, estradiol alone does not affect perseveration or reversal learning. However, low estradiol facilitates a 0.25 mg/day dose of haloperidol to reduce perseveration and improve reversal learning. Combined high estradiol and 0.25 mg/day haloperidol has no effect on perseveration or reversal learning, but high estradiol facilitates the effects of 0.13 mg/day haloperidol to reduce perseveration and improve reversal learning. Thus, in amphetamine-sensitized female rats, 0.25 mg/day haloperidol only improved perseveration and reversal learning when estradiol was low, while 0.13 mg/day haloperidol only improved these cognitive processes when estradiol was high. These findings suggest that estradiol facilitates the effects of haloperidol to improve perseveration and reversal learning in a dose-dependent manner.