پتانسیل حرکتی موتور در طی آماده سازی پاسخ تشخیص اختلالات عملکردی بین مغزهای غالب و غیر غالب وجود دارد

Transcranial magnetic stimulation (TMS) of the motor cortex produces motor-evoked potentials (MEPs) in contralateral muscles. The amplitude of these MEPs can be used to measure the excitability of the corticospinal tract during motor planning. In two experiments, we investigated learning-related changes in corticospinal excitability as subjects prepared to respond in a choice reaction-time task. Subjects responded with their left or right hand to a left or right arrow, and on some trials the arrow was immediately preceded by a warning cue that signaled which response would be required. TMS was applied to the motor cortex during the warning cues, and MEPs were measured in the dominant or non-dominant hand. We observed changes in corticospinal excitability during the warning cue, but these depended on which hand the subject was preparing to respond with, and how experienced they were with the task. When subjects prepared to respond with the non-dominant hand, excitability increased in the non-dominant hemisphere and decreased in the dominant hemisphere. These changes became stronger with task experience, and were accompanied by behavioral improvements in the task. When subjects were preparing a dominant-hand response, the non-dominant hemisphere was suppressed, but this effect disappeared as subjects gained experience with the task. There were no changes in the dominant hemisphere before dominant-hand responses. We conclude that preparing to respond with the non-dominant hand involves temporarily reversing an asymmetry in excitability that normally favors the dominant hemisphere, and that this pattern is enhanced by learning during the task.