دانلود مقاله ISI انگلیسی شماره 153251
ترجمه فارسی عنوان مقاله

تغییرات ماده سفید به سینگولوم و فورنیک پس از تولد بسیار زودرس و ارتباط آنها با توابع شناختی

عنوان انگلیسی
White matter alterations to cingulum and fornix following very preterm birth and their relationship with cognitive functions
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
153251 2017 10 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : NeuroImage, Volume 150, 15 April 2017, Pages 373-382

پیش نمایش مقاله
پیش نمایش مقاله  تغییرات ماده سفید به سینگولوم و فورنیک پس از تولد بسیار زودرس و ارتباط آنها با توابع شناختی

چکیده انگلیسی

Very preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in memory abilities and functional neuroanatomical brain alterations in medial temporal and fronto-parietal areas. Here we investigated the relationship between structural connectivity in memory-related tracts and various aspects of memory in VPT adults (mean age 19) who sustained differing degrees of perinatal brain injury (PBI), as assessed by neonatal cerebral ultrasound. We showed that the neurodevelopmental consequences of VPT birth persist into young adulthood and are associated with neonatal cranial ultrasound classification. At a cognitive level, VPT young adults showed impairments specific to effective organization of verbal information and visuospatial memory, whereas at an anatomical level they displayed reduced volume of memory-related tracts, the cingulum and the fornix, with greater alterations in those individuals who experienced high-grade PBI. When investigating the association between these tracts and memory scores, perseveration errors were associated with the volume of the fornix and dorsal cingulum (connecting medial frontal and parietal lobes). Visuospatial memory scores were associated with the volume of the ventral cingulum (connecting medial parietal and temporal lobes). These results suggest that structural connectivity alterations could underlie memory difficulties in preterm born individuals.