دانلود مقاله ISI انگلیسی شماره 75988
ترجمه فارسی عنوان مقاله

کاهش شناختی ذهنی پیش بینی کننده بدتر شدن وضعیت در افراد شناخته شده طبیعی مبتلا به بیماری پارکینسون است

عنوان انگلیسی
Subjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson's disease
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
75988 2014 5 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 35, Issue 7, July 2014, Pages 1739–1743

ترجمه کلمات کلیدی
بیماری پارکینسون، کاهش ذهنی شناختی، اختلال شناختی خفیف، روانشناسی معنایی، حافظه تمام عیار
کلمات کلیدی انگلیسی
Parkinson's disease; Subjective cognitive decline; Mild cognitive impairment; Semantic fluency; Visuospatial memory

چکیده انگلیسی

Increasing evidence suggests that subjective cognitive decline (SCD) is a potential predictor of future cognitive decline or dementia. We investigated whether SCD in patients with Parkinson's disease (PD) is a predictor of future cognitive decline. Forty-six cognitively normal patients with PD were selected using comprehensive neuropsychological tests, and classified depending on the presence (PD-SCD+, n = 25) or absence of SCD (PD-SCD−, n = 21). After a mean follow-up of 2.4 years, we repeated the cognitive assessments with the same subjects. The clinical characteristics and cognitive performance of the 2 groups did not differ at baseline. At the follow-up assessment, 11 patients in the PD-SCD+ group (44.0%) and 2 in the PD-SCD− group (9.5%) were diagnosed with mild cognitive impairment (MCI), and the PD-SCD+ patients showed more rapid decline in semantic fluency and visuospatial memory tasks than those in the PD-SCD− group. A multivariate logistic regression analysis showed that presence of SCD (odds ratio, 8.378; 95% confidential interval, 1.472–47.683, p = 0.017) and higher Unified PD Rating Scale motor score of 20 or more (odds ratio, 4.539; 95% confidential interval, 1.004–20.528; p = 0.049) were risk factors for incident MCI. Present results demonstrate that SCD in cognitively normal patients with PD is an independent risk factor for incident MCI and acts as a predictor for future cognitive decline.