تظاهرات فضایی در سگ گاو: نشانگر زودگذر کاهش شناختی در یک مدل پیری انسانی و زوال عقل

Visuospatial learning and memory impairments are an early marker for age-related cognitive decline and Alzheimer’s disease. Similar to humans, aged dogs show visuospatial learning and memory deficits (Adams et al., 2000b). One hundred and nine beagle dogs ranging between 0.25 and 11.99 years were tested on a visuospatial delayed non-matching to position (DNMP) task to better characterize the progression of visuospatial deficits in the dog. Age predicted 48.2% of the variability in learning the DNMP, with dogs ranging from 1 to 11.99 years generally making more errors with increasing age. By contrast, puppies (<1 year) likely were showing developmental deficits, possibly due to an immature prefrontal cortex. Mild visuospatial deficits were detected by 6 years, which precedes the typical onset of amyloid-β (Aβ) accumulation in the dog brain by two years, and can serve as an early marker for cognitive decline in the dog. These findings suggest that (1) age-related changes in visuospatial function in the dog models that seen in humans, further validating the dog as a model for human aging and dementia; and (2) other mechanisms, such as oxidative stress, soluble Aβ oligomers or cholinergic deficits, are likely contributing to the early impairment.