کلسترول و اکسیسترول کل: مارکرهای اولیه برای کاهش شناختی در سالمندان؟

Lower cholesterol at baseline was negatively associated with both general cognition (p = .012) and information processing speed (p = .045). ApoE modified the association between cholesterol and cognitive decline, and the association between the ratio of 27-hydroxycholesterol to cholesterol and cognitive functioning. In ApoE ɛ4 carriers, lower cholesterol was related to a higher rate of decline on information processing speed (p = .006), and a higher ratio of 27-hydroxycholesterol to cholesterol was related to a lower level of general performance (p = .002) and memory functioning (p = .045). The results implicate that lower total cholesterol may be considered as a frailty marker, predictive of lower cognitive functioning in elderly.