دانلود مقاله ISI انگلیسی شماره 76084
ترجمه فارسی عنوان مقاله

عملکرد تیروئید و زوال شناختی در تابع MRC شناختی و مطالعه سالمندی

عنوان انگلیسی
Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
76084 2008 10 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 33, Issue 7, August 2008, Pages 1013–1022

ترجمه کلمات کلیدی
اختلالات تیروئید؛ TSH؛ FT4؛ زوال عقل؛ حافظه؛ شناخت
کلمات کلیدی انگلیسی
Thyroid disorders; TSH; FT4; Dementia; Memory; Cognition

چکیده انگلیسی

In conclusion, elderly patients with cognitive impairment should always be assessed for hypothyroidism. It is unclear why high normal FT4 levels were independently associated with accelerated cognitive decline in those without overt thyroid disease. Other studies found that thyroxine can generate oxidative stress and damage neurons. Treatment with thyroxine in those without thyroid disease (as is sometimes done in anti-ageing clinics) is thus not recommended on the basis of these data and the optimal therapeutic level in the elderly may be lower than is assumed.