دانلود مقاله ISI انگلیسی شماره 77152
ترجمه فارسی عنوان مقاله

اثر سن در ریتم شبانه روزی نوع وحشی موش جهش یافته ساعت هتروزیگوت مشابه است

عنوان انگلیسی
Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
77152 2004 7 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 25, Issue 4, April 2004, Pages 517–523

ترجمه کلمات کلیدی
پیری - ریتم شبانه روزی؛ ساعت؛ جهش ساعت
کلمات کلیدی انگلیسی
Aging; Circadian rhythm; Clock; Clock mutation
پیش نمایش مقاله
پیش نمایش مقاله  اثر سن در ریتم شبانه روزی نوع وحشی موش جهش یافته ساعت هتروزیگوت مشابه است

چکیده انگلیسی

The amplitudes of many circadian rhythms, at the behavioral, physiological, cellular, and biochemical levels, decrease with advanced age. Previous studies suggest that the amplitude of the central circadian pacemaker is decreased in old animals. Recently, it has been reported that expression of several circadian clock genes, including Clock, is lower in the master circadian pacemaker of old rodents. To test the hypothesis that decreased activity of a circadian clock gene renders animals more susceptible to the effects of aging, we analyzed the circadian rhythm of locomotor activity in young and old wild-type and heterozygous Clock mutant mice. We found that the effects of age and the Clock mutation were additive. These results indicate that age-related changes in circadian rhythmicity occur equally in wild-type and heterozygous Clock mutants, suggesting that the Clock mutation does not render mice more susceptible to the effects of age on the circadian pacemaker.